Predicting Age of Onset in Familial Essential Tremor: How Much Does Age of Onset Run in Families?
نویسندگان
چکیده
منابع مشابه
Predicting age of onset in familial essential tremor: how much does age of onset run in families?
BACKGROUND The extent to which age of onset of essential tremor (ET) aggregates in families is unknown; hence, it is unclear whether information about the age of onset in one family member can be used to predict the age of onset in others. METHODS ET probands and relatives were enrolled in a genetic study at Columbia University. RESULTS Data from 26 probands and 52 relatives were analyzed. ...
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BACKGROUND Reliable estimates on the age of onset between familial and sporadic cancers are important for etiological understanding and clinical practice. Specific studies on the age of onset of familial cancer compared with sporadic cancer are less common than studies on familial risks and these are almost lacking for rare cancers. MATERIALS AND METHODS The Swedish Family-Cancer Database was...
متن کاملTesting for familial correlation in age-at-onset.
The analysis of family-study data sometimes focuses on whether a dichotomous trait tends to cluster in families. For traits with variable age-at-onset, it may be of interest to investigate whether age-at-onset itself also exhibits familial clustering. A complication in such investigations is that censoring by age-at-ascertainment can induce artifactual familial correlation in the age-at-onset o...
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conclusions low onset age of smoking cigarettes, high novelty seeking and low cooperativeness in opiate dependents are among the important personality traits in future use of drugs that can predict the subsequent onset of using opiate drugs. results opiate addicts had higher scores in novelty seeking dimension and lower scores in cooperativeness compared to nicotine addicts. the onset age of sm...
متن کاملRobust age at onset linkage analysis in nuclear families.
OBJECTIVE Standard methods for linkage analysis ignore the phenotype of the parents when they are not genotyped. However, this information can be useful for gene mapping. In this paper we propose methods for age at onset genetic linkage analysis in sibling pairs, taking into account parental age at onset. METHODS Two new score statistics are derived, one from an additive gamma frailty model a...
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ژورنال
عنوان ژورنال: Neuroepidemiology
سال: 2013
ISSN: 1423-0208,0251-5350
DOI: 10.1159/000345253